14 best drugs for migraine
What is a migraine? This disease has been known since ancient times. Even in the ancient world, it was called hemicrania, which literally means "half of the head." Pontius Pilate had such a disease, and his sufferings are very colorfully described in M. Bulgakov’s cult novel The Master and Margarita.
Despite the ancient history, migraine and still keeps its secrets. Here are some of them: migraine can not be diagnosed using any method of research, even the most perfect. Neither computed nor magnetic resonance imaging will show it. No instrumental way can do it.
Why is this so? The fact is that migraine refers to angiocephalgia, or a headache of vascular origin, and is completely reversible, without any changes in the vessels. Without going into details, one can only say that at first the vessels of the brain narrow, or experience a spasm. The patient does not feel this phase. But after the spasmed vessels expand, they do it in abundance. And such a rapid and excessive expansion of blood vessels and causes an attack of a characteristic headache. After this, the vessels regain their usual physiological tone, and after the attack no data for this disease exists anymore, except for the colorful story of the patient himself. Therefore, migraine is still diagnosed by questioning the patient, if there are special signs of this disease.
The second secret of migraine is that sometimes the abolition of all drugs that the patient has been unsuccessfully treated for many years, leads to improvement or even recovery. In some cases, refusing to consume large amounts of chocolate, nuts and cheese leads to the disappearance of headaches, and in young women, stopping the oral contraceptives described in the previous rating also quite often leads to complete deliverance from all seizures.
Finally, migraine is often not diagnosed at all, because patients take it for a normal headache, and do not go to the doctor. How to determine this condition? Therefore, before listing effective and popular drugs for the treatment of migraine, it is necessary to name the necessary criteria for this disease so that the reader can compare them with the facts and complaints that are available.
When can we talk about migraines?
Migraine has characteristic symptoms. These are headache attacks, most often one-sided. Usually, the pain at the beginning is dull, and then it begins to throb and intensify. Very often, this throbbing pain is localized in the eye, and greatly limits the patient's activity and impairs his quality of life. Most often, such attacks occur once or twice a month, and the debut of the disease occurs in adolescence or adolescence. In some cases, women have a clear association of migraine with the period of menstruation. A typical migraine attack proceeds as follows.
In the beginning, before the appearance of a headache in a person, the mood and appetite behavior changes.An hour before it starts, various visual disturbances often occur. The patient sees flashes of light, zigzags, balls, or points. Sometimes there are, however, less often, various feelings of numbness and tingling in the limbs. Weakness or transient speech disorders are very rare. This condition is called migraine aura.
Then there is a headache that can last from 4 hours to three days. During this period, besides typical pulsating pain, nausea or vomiting, severe intolerance of light and sound, the patient is very anxious to retire in a dark, cool and quiet room, and one of the ways to alleviate the condition is to pull the head with a towel or handkerchief, or squeeze it with hands . Usually vomiting occurs at the height of a headache, and patients are very much waiting for it, because they know that after vomiting, their condition improves. Then everything subsides, and the patient receives a light interval until the next attack.
This rating includes tools that are indicated for treating an attack, when the headache has already begun, and means for preventing migraine. Consider pills, from the softest to potent. They are used to treat severe forms of migraine, medium and conditions in which there is no significant disability.
Rating of the best drugs for migraine
| Nomination | a place | Name of product | price |
| The best drugs for the treatment of migraine attacks | 1 | Ultra Citramon (Askofen - P) | 91 ₽ |
| 2 | Sedalgin-Neo | 207 ₽ | |
| 3 | Caffetine | 96 ₽ | |
| 4 | Solpadein (Passage) | 84 ₽ | |
| The best triptans: the treatment of severe attacks | 1 | Emigran (Amigrenin, Sumamigren, Rapimed, Sumig, Triigren) = Sumatriptan | 262 ₽ |
| 2 | Zomig (Migrepam) = zolmitriptan | 750 ₽ | |
| 3 | Relpax | 390 ₽ | |
| Top Ergotamine Drugs | 1 | Bellatamininal | 140 ₽ |
| 2 | Ergotamine | 190 ₽ | |
| 3 | Nomigren | 524 ₽ | |
| The best drugs for the prevention of migraine | 1 | Amitriptilline | 28 ₽ |
| 2 | Anaprilin (Obzidan, propranolol) | 46 ₽ | |
| 3 | Verapamil | 57 ₽ | |
| 4 | Valproaty: Konvuleks, Depakin, Depakin - Chrono | 133 ₽ |
The best drugs for the treatment of migraine attacks
Rating means intended for the treatment of migraine, open the most gentle means with which usually begin the treatment of this angiocephalgia. These are non-steroidal anti-inflammatory drugs, many of them contain caffeine, the purpose of which is to narrow excessively dilated vessels. Some of these drugs contain codeine, and they are prescribed only by special prescriptions, and you simply cannot get them from a pharmacy. But it is they that are very good drugs that can help relieve an attack of a typical and pulsating headache.
Medications for low-intensity pain, which slightly degrades the quality of life:
Ultra Citramon (Askofen - P)
Rating: 4.9
Many of us are familiar from childhood with Citramon, who is discharged with a headache. One of the active drugs is the modification of Citramon Ultra. This product contains caffeine, acetylsalicylic acid and paracetamol. This combination is a successful combination that helps reduce headaches associated with excessive expansion of blood vessels. The ingredients are selected in such a way that they mutually potentiate, or enhance the action of each other. At the beginning of a migraine attack, it is necessary to take from 1 to 3 tablets for adults 3 times a day, but not more than 6 tablets. Citramon produces many domestic companies, for example, the company Obolensky, Farmvilar, and other manufacturers. The average cost of one package of Citramone Ultra per 20 tablets is 70 rubles.
Advantages and disadvantages
The advantage of this drug is a mild action, minor contraindications, which include the period of pregnancy and lactation, children under 15 years old (aspirin intolerance). Citramon is widely distributed in pharmacies, and it is easy to get it.It is a cheap drug, and it is quite possible to start the medicinal treatment of migraine. The disadvantage is the inability of Citramon to stop serious migraine attacks associated with a prolonged headache.
There are a lot of medications that contain caffeine in combination with other NSAIDs, and we will not list them all. Therefore, we next proceed to the means that are discharged according to special prescriptions, because they contain codeine.
Sedalgin-Neo
Rating: 4.8
This medicine is more serious because it contains, in addition to caffeine and paracetamol, which is part of the previous drug, also analgin, or metamizole sodium, the anticonvulsant component phenobarbital, and the narcotic component codeine. Therefore, Sedalgin Neo in pharmacies simply will not be sold to you, because it contains an opioid drug. But it is more effective in migraines than Citramon, and in addition to reducing vascular headache, it reduces intracranial pressure, after an attack increases psychomotor activity, as well as mental and physical performance. It is necessary to use this medicine in adult patients one tablet three or four times a day, but not more than 6 tablets. Sedalgin Neo is produced by the Bulgarian company Balkanfarm, and a pack of 10 tablets costs 200 rubles.
Advantages and disadvantages
The disadvantage of Sedalgin Neo, like all other drugs containing codeine, is a delicate situation. On the one hand, they help well for migraines and vascular headaches, but on the other hand, they are not special anti-migraine drugs, and therefore doctors prescribe them with some resistance, because it is necessary to thoroughly justify the purpose of codeine-containing drugs. On the other hand, this remedy helps some people so much that it is a favorite medicine, and they visit doctors only for extracting such prescriptions. Also a disadvantage can be considered overdose phenomena, when drowsiness, dry mouth, weakness and dizziness occur. It is not recommended to take a large dose of the drug at night, since codeine can lead to respiratory depression, especially in patients with sleep apnea, chronic hypoxia and high body weight.
Treatment of moderate seizures
Caffetine
Rating: 4.7
The composition of Caffetine includes the opioid narcotic component codeine, non-steroidal anti-inflammatory agent paracetamol, caffeine, and also propyphenazone, which has a psychostimulant effect. Among the indications for the use of Caffetine in the first place is a migraine, and only then the pain of another origin, such as muscle pain, toothache, joint pain and other types of it. But at the present time it is difficult to imagine a doctor who would prescribe a medicine for muscle or joint pain, which includes codeine. But with regard to migraine, Caffetine shows high activity, contributing to the return of the vessels of normal tone and reduction of pain.
This drug is administered one tablet 3 to 4 times a day, and if the patient has a strong, one-sided and throbbing headache with nausea, he is taken by surprise, then you can take two tablets at once with severe pain. During the day it is not recommended to take more than 6 tablets, and the course of treatment should not exceed 5 days without consulting a doctor. Caffetine is produced by the Macedonian pharmaceutical company Alkaloid, and one pack of 12 tablets will cost about 180 rubles.
Advantages and disadvantages
Caffetine's disadvantage is that it is difficult to prescribe a drug, because if only Caffetine helps, as is sometimes the case, then there is a need to convince the doctor (if you could not come to an appointment with your specialist) that you need this particular remedy. This drug is also not always the case in pharmacies.But in the event that the patient has a typical migraine and Caffetine helps him, then the person constantly carries pills with him, and never leaves them. However, we must remember that this remedy is contraindicated for severe disorders of the liver and kidneys, with a reduced number of leukocytes, and other disorders of blood formation. It can not be taken with anxiety and panic attacks, with severe hypertension, with insomnia, as well as during pregnancy and lactation. In addition, the drug has side effects, such as an increased irritability and palpitations.
Solpadein (Passage)
Rating: 4.7
Solpadein is also a relatively inaccessible drug. It contains three simple ingredients that work well for a common type of migraine. These are codeine, caffeine and Paracetamol. Codeine and caffeine are also called psycholeptics, and one of them is an opioid narcotic analgesic. As in the past case, migraine is the first and main indication for taking this drug. The product is available in capsules, tablets, or soluble tablets.
Apply Solpadein, two tablets, three or four times a day, but not more than 4 times, and no more than 8 tablets per day. In severe headache, it can also be indicated for children, but the maximum dosage is half as much, and children should not be given more than 1 tablet per reception. Solpadein produces well-known company Glaxo Smith Klein, and the cost of one package with 12 soluble tablets is 195 rubles.
Advantages and disadvantages
Both advantages and disadvantages are common with this drug with drugs that contain codeine and caffeine. It is contraindicated in severe bronchial asthma and respiratory failure, with increased intracranial pressure, during pregnancy. When breastfeeding Solpadein "can be used, but always after consulting a doctor." This phrase in the instruction, for the Russian conditions, is obviously meaningless, since it is impossible to buy the drug without a doctor's prescription in Russia. Of the side effects, nausea, dizziness, insomnia and nervous excitement with a tendency to constipation are most common. But in that case, if the drug is chosen correctly, and the dosage does not exceed the specified limits, then it significantly alleviates the condition of the patient with migraine, and relieves uncomplicated headache.
The best triptans: the treatment of severe attacks
We have listed some over-the-counter and prescription drugs that, in some cases, are directly indicated for the treatment of migraine, but are not specifically designed to combat this pathology. Therefore, no more than 10% of all patients with migraine will be completely satisfied with the drugs listed above.
Drugs from the triptans group are much more effective. These drugs constrict the arterial blood vessels of the brain, which will be dilated during migraine attacks, and cause headaches. When using triptans, especially 2 generations, headache, nausea and vomiting disappears very quickly. But, during treatment, it is impossible to immediately start triptans, and begin with them. These drugs are “heavy artillery,” and first you need to try to treat a migraine with no drugs at all, or nonsteroidal anti-inflammatory drugs in combination with caffeine.
In no case can not use drugs from the group of triptans for the prevention of migraine, then, when the head does not hurt, but can get sick. Why is this so? These drugs constrict the blood vessels of the brain. And in the event that they are excessively expanded, then triptans help relieve pain. And if they have not yet expanded, the triptans will narrow them to such an abnormal state that it will significantly reduce cerebral blood flow.
And if the patient has any risk factors, such as atherosclerosis of the cerebral arteries, then such unwise use of triptans for prophylaxis may even lead to a stroke. They should be taken only when an attack begins and there are already symptoms of a typical headache. Consider the main drugs from this group that are used by doctors.
Emigran (Amigrenin, Sumamigren, Rapimed, Sumig, Triigren) = Sumatriptan
Rating: 4.9
The first drug, created specifically for the treatment of migraine and migraine-like angiocephalgia, and it affects the metabolism of serotonin. According to its chemical structure, it is a selective serotonin receptor agonist. It stimulates these receptors, which are located in the blood vessels of the arterial link of the brain, and their stimulation leads to a narrowing of blood vessels. A pronounced clinical effect associated with a reduction in headache and the painful symptoms of migraine, on average, develops 40 minutes after taking one 100 mg tablet, or 15 minutes after intranasal administration.
Intranasal administration is an introduction to the nostril of the spray, since the product is also available in this form. It is very important that the spray should be sprayed into that nostril, which is on the side of the headache. An immigrant is able to arrest the symptoms of an attack in more than 70% of all patients. In that case, after taking the drug or the introduction of the spray, there was no improvement in the effect, then within a day you can take the second dose. At the same time, the maximum dosage of Imigrana during the day should not exceed 300 mg when taking tablets, that is, three tablets of 100 mg or 6 tablets of 50 mg, and with intranasal administration it is impossible to exceed the amount of two doses of 20 mg of spray in each.
Emigran, which is the original drug, the company Glaxo Smith Klein. A package containing 2 tablets of 100 mg costs an average of 400 rubles, and a nasal spray will cost 500 rubles. for a small package. The domestic equivalent of Amigrenin in the same dose for tablets will cost 188 rubles, and Sumamigren (Polpharma) will cost 135 rubles.
Advantages and disadvantages
The advantages of the Imigran are obvious. It is the “gold standard”, and the first special anti-migraine drug, which has a large evidence base, it was created specifically for the relief of migraine attacks. The effectiveness of this tool was mentioned above. However, it also has side effects, which are most often expressed in a feeling of pressure in the chest, as well as a flush of blood to the head. In addition, Imigran can not be prescribed to patients in whom the doctor assumes any cardiac pathology without a preliminary examination. The tool is prescribed with very great care in patients with epilepsy, with severe damage to the liver and kidneys. Therefore, Imigran is sold on prescription, and it is necessary to begin treatment with a minimum dosage - use of a 50 mg tablet, or one dose of spray per day in the presence of typical pain.
Zomig (Migrepam) = zolmitriptan
Rating: 4.8
Zomig contains zolmitriptan - it is a second-generation drug triptans. He is also able to stop a painful attack in case of migraine, reduces the painful feeling of nausea, eliminates the fear of photophobia and photophobia. Usually, the effect is manifested within an hour after taking the drug, and the recommended dosage for stopping an attack is taking one 2.5 mg tablet.
If the pain persists, then during the day, just as with Imigran, you can take the same dose again, but not earlier than 2 hours after taking the first pill. As in the previous cases, it is important to take this remedy as early as possible, but only when the head is already sick. It is necessary to carefully monitor the presence of repeated attacks, so that the maximum daily dosage does not exceed 15 mg in any case.Zomig company produces Astra Zeneka, and its price is quite high. In addition, there are domestic counterparts. Thus, the drug Migrepam, which is produced by the domestic company Obolensky, will cost only 216 rubles per pack of 2 tablets at the same dosage.
Advantages and disadvantages
Zomig is a second-generation drug, and this is advantageously distinguished by its early onset of action: on average, the pain disappears or significantly decreases after 20 minutes. He has a very low dose compared to Imigran. Zomig’s efficiency is also higher, if for Imigran it was 70%, then zolmitriptan is already 80%. It also reduces the need to re-take this medication, it is required only for every fifth patient. In addition, zolmitriptan can be used in patients with cardiovascular disease, but still according to the decision of the doctor. The side effects of Zomig are significantly less pronounced. This remedy can also be used to treat migraine status, or a serious condition in which the headache lasts longer than 72 hours, and in some cases up to 5 days.
Relpax
Rating: 4.8
Relpaks, or eletriptan, is also a modern drug from the group of triptans. Its advantage is that it activates serotonin receptors, which are located mainly in the carotid arteries, and therefore Relpax is more inclined to influence the cerebral vessels than receptors in other parts of the arterial bed, for example, in the coronary arteries.
It is produced in the form of tablets of 20 and 40 mg, and for the relief of a severe migraine attack, one tablet of 40 mg must be taken, and, as in previous cases, and if during the day the pain has resumed, you can take the same dosage again. If, after 2 hours after the first dose, the headache has not passed, then you can repeat the reception of the same dose, but not earlier than after 2 hours. The drug is produced by the German company Pfizer, and the cost of the package consisting of 2 40 mg tablets is 550 rubles.
Advantages and disadvantages
The advantage of Relpaks can also be called high efficiency, but its main advantage is the selective, selective effect on the vessels of the brain. No need to explain that the narrowing of all blood vessels (non-selective effect) is not always necessary, and even harmful. If there is a spasm of the coronary arteries, there may be a shortage of blood flow, which is what doctors fear in cardiovascular disease, carefully checking patients for the presence of coronary heart disease. The drug Relpaks practically has no such side effects, and due to this, it can be more successfully prescribed in elderly patients with an increased risk of cardiovascular diseases, in particular in IHD.
However, like any potent drug, it has symptoms of overdose with the development of high blood pressure, and there is a list of contraindications, such as lactation, pregnancy, severe liver disease. You can not combine this drug with ergotamine or its derivatives. It is also contraindicated for the treatment of specific forms of migraine, which include hemiplegic, basilar or ophthalmoplegic migraine, as this disease does not always occur exactly as described above.
Top Ergotamine Drugs
It would seem that triptans are quite enough for the relief of severe migraine attacks. What is the next group of ergotamine drugs, or ergot alkaloid, then? These funds help patients who clearly have the very first phase of a migraine attack, or the prodromal stage, which sometimes begins even a few days or hours before the headache. Some of her signs have been described above. It is these patients who are prescribed ergotamine.
It can be introduced into the body in pills by mouth, sublingually under the tongue, in the form of rectal suppositories, intravenously and even in the form of inhalations.Since patients with migraine are often sick, ergotamine is most commonly used for resorption, in the form of tablets under the tongue, and also rectally. Typically, a single dose that relieves a migraine attack is 2 mg, and during one attack, no more than three such doses can be taken during the day. The interval should not be less than half an hour. There is a significant limitation: within one week, with frequent attacks, ergotamine preparations can be taken no more than 9 times. We list some of the funds from this group.
Bellatamininal
Rating: 4.9
Bellatamininal is the mildest drug that belongs to sedatives, and contains in addition to ergotamine tartrate, also belladonna alkaloids and phenobarbital. But the dose of ergotamine in it is quite small, and one tablet contains it only 0.3 mg. Therefore, this drug is used in patients with mild migraine. This remedy is indicated for use on one tablet 3 times a day after meals, and when the onset of migraine pain, the dosage can be doubled. In addition to migraine, Bellataminal is indicated for nervous excitability and neurosis, with the development of insomnia. This company produces the domestic company Farmvilar, and one pack of 30 tablets can be purchased at an average price of 145 rubles.
Advantages and disadvantages
The advantage of this drug is a mild action, and the ability to apply it in milder forms of migraine. However, it is inexpensive, but it is not always possible to get it from pharmacies. He has contraindications such as pregnancy, vascular spasm, glaucoma. In addition, it can cause side effects such as dry mouth and drowsiness, and in case of overdose - dilated pupils, dizziness and urinary retention.
Ergotamine
Rating: 4.8
Ergotamine is produced in the form of ergotamine hydrotartrate, and in addition to the vasoconstrictor, that is, vasoconstrictor action, it significantly increases the tone of the uterus muscles.
Attention! Ergotamine and its analogues are absolutely contraindicated in patients with migraine during pregnancy.
It is also contraindicated for migraine, which is accompanied by focal neurological disorders, that is, visual impairment, weakness in the limbs or speech disorder. Therefore, ergotamine should be prescribed only by a qualified specialist who treats vascular headaches.
In case of migraine, the drug is prescribed several hours before the expected attack, while the drug is convenient to use in drops, 20 drops per dose. At the onset of a headache, either one 2 mg tablet or two tablets is taken under the tongue. After 2 hours of inefficiency, you can take another 2 mg tablet under the tongue, but within 24 hours you cannot exceed a dose of 10 mg.
Advantages and disadvantages
The advantage of ergotamine can be considered a high activity in patients with a pronounced prodromal phase, the presence of various dosage forms intended for very different administrations, and the disadvantage is a pronounced shortage of these drugs in pharmacies. In addition, ergotamine has a lot of contraindications, and it is especially important that he was not prescribed to pregnant women in any period of gestation.
Nomigren
Rating: 4.7
This drug is a combined anti-migraine, which contains five different components, including ergotamine at a dosage of 0.75 mg per tablet. In addition, the tablet contains caffeine, propiphenazone and other components. As a result, in addition to the anti-migraine effect, the agent produces an anesthetic and antispasmodic effect. It is shown Nomigren with migraine with a pronounced prodromal period, with other angiocephalgic syndromes, and the medication should be taken at the very beginning of the attack.
The maximum dose is two tablets, after half an hour you can take another pill or two, if the condition has not improved. The maximum daily dose is 4 tablets, and the maximum weekly dose is no more than 10 tablets.It is not recommended to use the drug for a long time, over 7 days. Nomigrene is produced by Bosnian Bosnalek company, one pack of 10 tablets costs 540 rubles.
Advantages and disadvantages
Like other preparations of ergotamine, Nomigrine is highly effective in patients with a pronounced prodromal period, but it cannot be used for prophylaxis, but only if a headache has already begun. An overdose can cause nausea or vomiting, general weakness and tinnitus. It is undesirable to prescribe it with other vasoconstrictor drugs, as this can lead to severe hypertensive crisis.
Caution: ergotism! Ergotamine drugs can not be taken longer than 7 days, because with prolonged use may be the so-called ergotism, or persistent and prolonged spasm of peripheral blood vessels.
This can manifest itself as marked impairment of sensitivity in the fingers, their blanching, cyanosis, even a decrease in vascular pulsation and the development of persistent ischemia, which, in the presence of aggravating factors such as obliterating endarteritis in the elderly, can even lead to gangrene. Therefore, treatment with ergotamine drugs should be carried out only under the supervision of a physician.
The best drugs for the prevention of migraine
Means for the prevention of migraine is quite necessary to apply outside the attack, when there is no pain, that's what they are meant for. Interestingly, many drugs that are successfully used for this purpose do not have such indications as “migraine prophylaxis” in official instructions. But this practice has long been known, and is used quite often. The introduction of such testimony into the official instructions is very difficult, since it requires a review of the funds, its re-registration, and expensive research that is completely unprofitable to the manufacturer, since the drug sells well and so.
Funds for the prevention of migraine should be prescribed not always, and not all, but only if the patient has a frequency of attacks more than 2 times a month, and if these attacks systematically violate his daily activity and work capacity.
Amitriptilline
Rating: 4.9
Amitriptyline is an old and fairly well-known tricyclic antidepressant, but its ability to prevent migraine attack is not at all associated with this anti-depressant effect. Amitriptyline is best administered for migraine at a dosage of 25 mg, giving it overnight, because at the very beginning of the prescription it can cause drowsiness. Then the dosage is gradually increased by 25 mg, that is, one tablet every week, during the month. The average dose of amitriptyline, which "works", is 100 mg per day, and the maximum is 200 mg per day. Amitriptyline is produced by a large number of domestic manufacturers, for example, the Ozone pharmaceutical association, and the average cost of a package of 50 tablets of 25 mg is only 30 rubles.
Advantages and disadvantages
The advantage of amitriptyline is low cost and widespread in pharmacies of any form of ownership, and the disadvantage is the need to prescribe it, and side effects on dosages close to the maximum. The patient may develop dry mouth, drowsiness, urinary retention or constipation. In some cases, the patient's body weight increases, and in this case, the prevention of migraine with amitriptyline should be abolished.
Anaprilin (Obzidan, propranolol)
Rating: 4.8
This drug is widely known and is used in cardiology to reduce blood pressure and to treat tachycardia, or heart palpitations. The drug belongs to the group of beta-blockers, and has long and successfully contributes to the prevention of migraine attacks.The average dosage of propranolol for the prevention of migraine is 80 mg per day, and if necessary, this dosage can be doubled and brought to 160 mg per day, but pulse control is necessary, since the drug can slow the number of heart contractions. In any case, the patient’s heart rate at rest should not be less than 60 beats per minute. Propranolol produces a large number of different pharmaceutical companies, and it is inexpensive. So, one pack of 50 tablets weighing 40 mg will cost, on average, 24 rubles
Advantages and disadvantages
Most often, propranolol is well tolerated. But in some cases, special care must be taken, patients with bronchial asthma may have bronchospasm and seizure. If the patient is athletic, or he has regular physical exertion, then, against the background of a significant patient load, the number of heart contractions will remain low, and this will lead to a lack of blood flow. As clinical practice shows, a large number of women suffering from migraine, for some reason, attend aerobics and fitness, therefore, such prophylaxis with beta-blockers is contraindicated for them. If the patient tolerates this remedy well, his typical seizures become less frequent and pass more gently.
Verapamil
Rating: 4.8
In the event that a patient needs a means to prevent migraine, but he cannot be prescribed Anaprilin or Amitriptyline, then calcium antagonists are successfully used. Verapamil with migraine is prescribed in the starting dosage of 180 mg at night, if necessary, you can increase it within a month, and bring to the dosage of 240 mg, this means is also taken once for the night. As a rule, Verapamil is well tolerated, the cost is low, and a pack of 30 tablets weighing 40 mg each will cost only 40 rubles, while the Verapamil is made by the Macedonian company Alkaloid.
Advantages and disadvantages
Verapamil is a good, mild remedy that can successfully prevent migraine attacks, and makes them more rare, they are more easily tolerated. Verapamil is cheap, available. But at the same time before the appointment it is necessary to exclude cardiovascular pathology, severe bradycardia, heart failure, various cardiac blockade and conduction disorders. Finally, it is impossible to combine the use of Verapamil with the use of beta-blockers, and when transferring from one group of drugs to another it is necessary to take a break. Also, it can not be applied to pregnant and lactating women. The drug can cause various side effects, especially when the dosage is increased. Therefore, prophylaxis with Verapamil, as well as in other previous cases, should be under the supervision of a physician.
Valproaty: Konvuleks, Depakin, Depakin - Chrono
Rating: 4.7
Finally, approaching the end of the transfer of drugs used for the prevention of migraine, valproic acid preparations, such as Konvulex or Depakine, should be noted. It is preferable to use long-lasting or prolonged action drugs. These include the means of Depakine Chrono. This is convenient because a single evening reception is possible. These remedies are specifically designed to treat epilepsy, but for the prevention of migraine, they are very good at a low dose that does not cure epilepsy. Sometimes the average dose, which causes a good effect in patients with migraine, is 650 mg per day, it needs to be divided into 2 doses, in the morning or in the evening. But in some cases, successful prevention of migraine is achieved with a dosage of 150 mg twice a day, or half a tablet of 300 mg. The cost of one bottle of 100 tablets of this dosage is 740 rubles. Depakine Chrono is produced by Sanofi.
Advantages and disadvantages
If we consider the drug Depakine Chrono, then there are 300 mg and 500 mg pills, and at the beginning of treatment it is quite enough to take one such 300 mg pill for the night.However, we must remember that this tool has a large number of contraindications and side effects. So, contraindications include acute and chronic diseases of the liver and pancreas, hereditary mitochondrial diseases, and it is not recommended to prescribe to women of childbearing age and pregnant women. And if you consider that the majority of migraine sufferers are just women, then before consulting you should consult a specialist.
Attention! This rating is subjective, is not advertising and does not serve as a guide to the purchase. Before buying, you should consult with a specialist.
