10 best liver products
Liver is not for nothing called the biochemical factory of our body. It constantly undergoes such a large number of various interconversions of substances, the synthesis of new compounds, the splitting of harmful and unnecessary molecules, that its temperature is much higher than that of other internal organs. Since the times of ancient mythology, we know that the priest inquiring the gods holds the smoking liver of a sacrificial animal in his hands. And this is true: the normal temperature of the liver exceeds 40 degrees, so you can imagine the intensity of the biochemical processes occurring in it.
The liver is responsible for the synthesis of most proteins in our body, for the creation of immunoglobulins, or antibodies. The liver synthesizes bile, which breaks down fats, it deals with the utilization and destruction of unwanted protein molecules and hemoglobin. But the liver itself almost never rests.
Recall that the digestive gruel formed in the intestine is absorbed into the intestinal wall, but does not immediately enter the bloodstream. All that is eaten by man, first passes through the portal circulatory system, or through the liver. Only after the liver has thoroughly checked every molecule formed and absorbed in the intestines, does it decide what to do with these proteins, fats, and carbohydrates. Some of them break down the liver, some of it modifies, and some - neutralizes. Some compounds that have been absorbed in the intestines never fall outside its limits. Therefore, those of us who think that the liver is resting at night are fundamentally wrong. The liver never rests. That is why she has such an amazingly high ability to regenerate cells.
Are there any effective ways to clean up the liver, care for the liver, or, as they say, “clean the liver”? Yes, there are. Only you need to understand that the liver is not a filter, not a rag or a sponge. Its ability to self-clean and self-renewing surpasses all imaginable and unimaginable possibilities and expectations. Therefore, the best way to protect her health is to follow the simple rules of a healthy lifestyle. But if this is not enough, then what drugs can support the normal state of the liver?
This rating includes the most effective and popular drugs from the group of plant and animal hepatoprotectors, as well as various compounds, drugs for the prevention of free radical oxidation, monodrugs. These choleretic drugs were not included in the rating, since their uncontrolled use in the presence of contraindications can lead to serious complications, up to rupture of the gallbladder. This can happen in the presence of mechanical damage: obstacles to the normal flow of bile. Therefore, the use of choleretic drugs is possible only after consultation, examination and prescription of a doctor.
Rating of the best drugs for the liver
| Nomination | a place | Name of product | price |
| Best Essential Phospholipids | 1 | Essentiale (Prozalyut pro, Phosphontsiale) | 260 ₽ |
| 2 | Phosphogliv (glycyrrhizic acid + phospholipids) | 457 ₽ | |
| 3 | Essliver forte (phospholipids + vitamins) | 276 ₽ | |
| Herbal preparations for cleaning the liver | 1 | Hepatrine (Lecithin) | 518 ₽ |
| 2 | Ovesol (extract of oats, turmeric, immortelle, mint) | 148 ₽ | |
| 3 | Liv 52 | 327 ₽ | |
| 4 | Karsil (milk Thistle) | 310 ₽ | |
| 5 | Baikal Taxifolin, or dihydroquercetin | 1 350 ₽ | |
| The best monotherapy drugs for the liver | 1 | Hepa-Mertz (Ornithine) | 825 ₽ |
| 2 | Heptral (admethionine) | 1 694 ₽ |
The best essential phospholipids for the liver
Open the group of hepatoprotectors so-called essential phospholipids. These are substances that are precursors of cell membrane structures. They contain derivatives of lecithin, phosphatidylcholine, derivatives of glycerophospholipids, inositol and sphingosine. The function of phospholipids is very important: to maintain the constancy of the composition of cell membranes, their electrical charge, and to ensure the plastic properties of cells.
The biological transport role of phospholipids in the transfer of fatty acids, cholesterol and fats is very important. Many of the compounds of this group are considered intracellular carriers of various compounds, and many functions of the furnace ultimately depend on their normal structure and metabolism.
Essentiale (Prozalyut pro, Phosphontsiale)
Rating: 4.9
The group of hepatoprotectors based on essential phospholipids is discovered by their ancestor, Essentiale, a drug that is not a combination, but contains only these ingredients derived from choline-based soybeans. As mentioned above, various destructive liver diseases begin at the cellular level, with disruption of cell membrane structures. These essential phospholipids are used to restore them.
According to the manufacturer, due to the higher content in the drug of unsaturated molecules, they are considered more active. In this regard, they are often embedded in the damaged areas of the membranes and contribute to their renewal. As a result of regular use of the drug, Essentiale leads to an increase in the synthetic and detoxifying properties of the liver.
It is recommended to use this drug for various chronic liver diseases, such as chronic hepatitis, alcoholic liver disease, fatty degeneration, in case of toxicosis in pregnant women. Essentiale improves the course of gallstone disease and chronic toxic liver damage. A separate indication for use is psoriasis, but as part of complex therapy. Essentiale capsules should be used 2 capsules 3 times a day, with meals. Essentiale is produced by the famous manufacturer Natermann from Germany, and the cost of one package of 90 capsules is 1,200 rubles. Accordingly, the course of admission during the month will cost 2400 rubles.
Advantages and disadvantages
The advantage of this drug will be its good tolerability: perhaps it is not shown only to patients with intolerance to soybeans - sources of phospholipids. It can cause minor side effects, which can include abdominal discomfort and weakened stools, along with allergic reactions. In addition, the tool is contraindicated at the age of less than 12 years, due to the lack of the required number of studies.
Phosphogliv (glycyrrhizic acid + phospholipids)
Rating: 4.8
Phosphogliv, in addition to a set of essential phospholipids, contains a plant component. In this case, it is the sodium salt of glycyrrhizic acid. Glycyrrhizin is the active biological substance of licorice root. Course taking the drug Phosphogliv can not only protect the liver from the harmful effects of toxic substances and active metabolites, but also has a membrane-stabilizing and immunogenic effect, which is to increase non-specific antiviral resistance. At the same time, the main element of the cell membranes contained in the preparation will be phosphatidylcholine. Due to glycyrrhizic acid, the agent has an anti-inflammatory effect.
Therefore, Phosphogliv is indicated in the complex treatment of not only toxic and alcoholic liver damage, but also in viral hepatitis B, C and Delta, in the complex treatment of liver fibrosis, or cirrhosis of various etiologies. It is used in adults and in children older than 12 years, just as in the past case - 2 capsules 3 times a day. The average duration of the course is usually 3 months, and the continuation is possible on prescription. Phosphogliv is produced by Pharmstandard, a domestic pharmaceutical company, a package of 50 capsules will cost an average of 500 rubles.
Advantages and disadvantages
The disadvantages of Phosphogliv can be attributed to a fairly high exchange rate. After all, a package of 50 capsules will end in 8 days, and a three-month course will require more than 10 such packages, and, accordingly, the total amount will exceed 5,000 rubles per course. On the other hand, the drug is well tolerated, has no drug interactions, and the incidence of various side effects does not exceed one case per 10,000 doses. But on the other hand, the tool can not be taken with signs of antiphospholipid syndrome, pregnant and lactating women, children under the age of 12 years. If there are symptoms of high blood pressure in the portal vein, that is, with the development of portal hypertension, care must be taken and the reception should be done as directed and under the supervision of a physician.
Essliver forte (phospholipids + vitamins)
Rating: 4.8
The next complex hepatoprotector is Essliver Forte. It is available in capsules, its manufacturer is the well-known pharmaceutical company Nizhfarm. This tool contains phospholipids in its composition, just like Essentiale, and the remaining payload is distributed almost equally to the various B vitamins, alpha-tocopherol and nicotinamide. Such a set of active ingredients allows not only to improve the hepatocyte membranes, but also has a lipid-lowering effect due to nicotinamide, reduces the level of glucose in the blood plasma.
The drug is indicated in the complex treatment of various acute and chronic liver diseases, in its alcoholic lesion, in cirrhosis, in the initial stages of chronic liver failure and in the complex treatment of drug addiction. Essliver is successfully used as a protective agent against the background of chemotherapy and radiotherapy in patients with cancer and in patients diagnosed with psoriasis. Apply Essliver Forte need for a standard dosage: two capsules from 2 to 3 times a day, with an average course of 3 months. The cost of one package of 50 capsules is 430 rubles.
Advantages and disadvantages
As in all previous cases, the advantage of this tool will be good tolerability and a small number of side effects associated mainly with individual intolerance (nicotinic acid). But in the event that a patient has really severe and active liver diseases, then only one hepatoprotective drug, if taken without other medicines, without diet, and without other methods of treatment, will not bring long-awaited results. He can cope with the above symptoms of the disease only in combination with other means. In addition, Essliver is not very convenient for long-term reception and at the same time an expensive tool. Just as in the past case, one pack is enough for almost a week of admission, and a three-month course will be quite expensive.
The best herbal preparations to clean the liver
Essential phospholipids are no longer present in the composition of these heptoprotectors, they are replaced either by individual fractions or by plant extracts. So, in Hepatrine there is lecithin, as a precursor of phospholipids, and as part of the drug Ovesol you can find turmeric, immortelle, mint and oat extract.All these drugs are also recommended in the complex treatment of various chronic inflammatory liver diseases, and for prophylaxis they can be used for chronic intoxication, bad habits and for non-compliance with the rules of a healthy lifestyle.
Hepatrine (Lecithin)
Rating: 4.9
This tool - the development of domestic pharmacists, and are biologically active additives, exhibiting antioxidant properties. It consists of an extract of milk Thistle, artichoke, and only one fraction, namely lecithin, acts as a source of essential phospholipids. Additionally, tocopherol and vitamins of group B are introduced into the preparation. In addition to the hepatoprotective and immunomodulating effects, Hepatrine has a very slight choleretic effect due to artichoke extract.
The indications for taking Hepatrine are as numerous as in the previous case. These are various chronic diseases of the liver and biliary ducts, chronic hepatitis, chronic alcoholic liver damage, the initial stage of cirrhosis of the liver, as well as the impact of adverse environmental factors and exogenous intoxication, including production. Hepatrine is used in healthy people, as a means for prevention, a source of vitamins.
It is necessary to use the drug one capsule twice a day with meals, the usual course of administration lasts about 1 month. Hepatrine is produced by the domestic pharmaceutical company CJSC Evalar, known for producing its nutritional supplements, and the cost of one pack of 60 capsules for 20 days of administration will be, on average, 520 rubles.
Advantages and disadvantages
All the biologically active supplements that we have reviewed are approximately included in one group at their price, and so far no price advantage of any of the preparations exists for another. But nevertheless, Hepatrine is administered one capsule twice a day, and this will still save on exchange rate differences. In addition, the course of treatment is only one month, unlike three, or even more than six months, when compared with some analogues. In addition, Hepatrine is considered a source of vitamins of group B in physiological dosages, and can be used successfully for the prevention of liver diseases, except for the period of pregnancy, breastfeeding, in children under 12 years of age. The drug is well tolerated, only minor dose-dependent allergic reactions are possible from side effects.
Ovesol (extract of oats, turmeric, immortelle, mint)
Rating: 4.8
In folk medicine, oats decoction has been actively used for a long time as a remedy for soothing liver inflammation and having a slight choleretic effect. Modern drug Ovesol created by the same pharmaceutical company CJSC Evalar. In addition to oats, it contains turmeric roots, immortelle flowers, peppermint leaves and volodushka. The tool is available in drops for ingestion and tablets. At the same time, oats are considered to be a source of amino acids, saponins and microelements. It removes toxins and eliminates bile stasis. Turmeric has a slight anti-inflammatory effect, and curcumin disinfects. The immortelle extract produces a mild antispasmodic effect.
Well-chosen components contribute to the normalization of bile formation and bile secretion, and are shown in the treatment of patients with chronic cholangitis and cholecystitis, without the presence of mechanical obstacles to the removal of bile. If there is an inflection in the neck of the gallbladder, and if there are concrements in the bile ducts and in the gallbladder, it is necessary to take the drug only by prescription. In case of drops, Ovesol is prescribed 25 drops 2 times a day, the course of treatment is one month with the course repeated 3 times a year. The cost of a bottle in 100 ml is, on average, 400 rubles.
Advantages and disadvantages
Ovesol is administered in drops, in which case it is quickly and well absorbed.A drug that affects bile formation and bile excretion should ideally be administered in a liquid form. Active ingredients affect various stages of the pathological process in cholecystitis and cholangitis, in which there is a slowdown in the process of bile formation, biliary excretion and a high risk of secondary infection in the biliary tract, especially in the presence of parasites. Therefore, the use of Ovesol in the treatment of chronic diseases of the biliary tract can reduce the dosage of antispasmodic drugs, antibiotics, and reduce the drug load on the liver. The cost of the drug is low, and its tolerability is good.
Liv 52
Rating: 4.7
Liv 52 is an effective drug that reduces pain in the liver, and it is based on ancient Ayurvedic Indian medicine. It consists of chicory and capers, black nightshade, cassia, tamarisk and yarrow. The composition of the formulation of this drug includes medicinal raw materials such as white eucalyptus, medicinal smoke, and about a dozen more plants not found on the territory of the Russian Federation. As a result, this compound has a protective and choleretic effect. Regular intake of this drug in front of various holiday feasts allows not only to reduce the unpleasant symptoms associated with the reaction of the biliary tract to fatty and spicy foods, but also to prevent the destruction of liver cells.
In the event that using LIH 52 in a healthy person, this drug, based on Ayurvedic medicine, will improve and stimulate digestion. It is necessary to apply LIV 52 2 tablets 2 times a day, both adults and children after 6 years. In the event that the patient has pain and pain in the right hypochondrium, a feeling of bitterness in the mouth, then the number of tablets can be increased to three, but always after a doctor's appointment. The drug is manufactured by the Indian company Himalaya, and the cost of one bottle of 100 tablets is 312 rubles, which is very inexpensive.
Advantages and disadvantages
The great advantage of the drug is the entry into it of various plant extracts, but each of them is in a small dosage. Such a balance does not allow this dietary supplement to have a bias towards biliary excretion, and the drug works very gently. The only limitation is that it should be carefully prescribed in case of acute gastrointestinal diseases, for example, in case of exacerbation of gastritis or duodenal ulcer. It can also be successfully used for chronic hepatitis of various etiologies, in the case of the development of fatty hepatosis, for the prevention of hepatotoxicity, for example, when prescribing various antibiotics, including anti-tuberculosis.
Karsil (milk Thistle)
Rating: 4.7
Kars is a popular monodrug that contains an analogue of silymarin, namely, an extract of the milk thistle fruit. This drug replaces the well-known milk thistle, which is not so easy to find in the wild. The tool is indicated for chronic liver damage, and above all - in the complex treatment of alcoholism. Kars is well reduces the manifestation of asthenia in withdrawal syndrome, improves appetite, reduces bitterness in the mouth and heaviness in the liver, accelerates the normalization of the digestion after leaving the binge. Karsil improves the function of hepatocytes in the initial stages of cirrhosis of the liver, fatty degeneration, as well as in case of poisoning with salts of heavy metals and in unfavorable environmental conditions. Kars is successfully used in the prevention of occupational pathology, as well as in radiation and chemotherapy, in the appointment of toxic drugs that can affect the liver.
Need to apply Kars 1-2 1-2 tablets 3 times a day, before meals. Kars can be washed down with plenty of water.For severe liver lesions in complex therapy, the dosage can be increased to 4 pills three times a day, and in the case of prophylaxis and supportive treatment Kars is applied one pill also three times a day. One package, which contains 180 tablets, on average costs 700 rubles, and it is produced by the Bulgarian company Sopharma. One such package is enough for a month, reception.
Advantages and disadvantages
Kars is very well tolerated, because it contains only one medicinal substance, but, on the other hand, its mode of administration is not very convenient: you need two, three, or even four tablets per reception, and the cost of the product is very high for food additives and prophylactic drugs. Therefore, if the patient has expressed complaints about the work of the liver and the hepatobiliary zone, such as bitter taste in the mouth after eating, heaviness in the right hypochondrium, intolerance to spicy, fatty foods, then you should first go to a doctor and then recommendations, either to take Kars, or to prescribe it in a low dosage, but combining it with taking other medications on the background of a diet.
Baikal Taxifolin, or dihydroquercetin
Rating: 4.7
Baikal Taxifolin is the most active and most purified of the preparations of dihydroquercetin, a plant antioxidant related to bioflavonoids. Usually preparations of dihydroquercetin, which are sold at retail in the form of various biological additives, have a low antioxidant activity. This is due to their chemical composition: almost all molecules of most commercial dihydroquercetins are polymers in varying degrees, which impairs their chemical properties.
Baikal Taxifolin, in contrast, has a unique single-crystal structure due to technology. This means that, being dissolved in the biological media of the body, all its molecules have the same structure, they are capable of dissociation and effective action. With respect to the liver, dihydroquercetin exhibits the same ability to restore cell membranes as phospholipids. Only he is not a donor of essential molecules, but simply prevents the destruction of membranes, inhibiting excessively pronounced mechanisms of free radical oxidation, or lipid peroxidation.
That is why monocrystalline dihydroquercetin, or Baikal Taxifolin, is indicated in the complex therapy of various chronic liver diseases. In the first place - this is chronic alcoholism, fatty hepatosis, chronic viral hepatitis B and C, the initial stages of cirrhosis of the liver. In complex therapy, Taxifolin Baykalsky is also recommended for diseases of the biliary tract. It is used with success and as a preventive measure, especially if a person has been in an unfavorable environmental situation for a long time, and his diet is far from a healthy lifestyle. It is necessary to take Taxifolin one capsule once a day, each capsule contains 60 mg of this ultra-pure and active compound. The average course of treatment is from 1 to 2 months, and the cost of this drug currently ranges from 950 to 1350 rubles per pack of 30 capsules.
Advantages and disadvantages
The great advantage of Taxifolin can be considered well tolerated and the absence of symptoms of overdose, it is produced from Siberian larch wood. In its pure form, it is recommended to use it for prophylaxis, but in the presence of chronic diseases of the hepatobiliary zone and their exacerbation - as part of complex therapy. The relative disadvantage of this drug is that it is rarely found in the retail chain in pharmacies, since at present almost the entire volume of the drug produced by the domestic company Siberian Cedar is exported. But Taxifolin can be purchased through a network of representatives.
The best monopreparations for the liver
In conclusion, you should give to your attention some monopreparations that significantly improve liver function, and especially in severe lesions, when it comes to the signs of chronic liver failure. Typically, these tools help to significantly improve the quality of life, prolong life in patients with liver failure and avoid early onset of so-called hepatic encephalopathy, in which cognitive functions are significantly impaired. On sale in pharmacies you can see the two most popular in the Russian Federation. This Heptral and Gepa-Merz.
Hepa-Mertz (Ornithine)
Rating: 4.9
Gepa-mertz is a preparation containing only one active ingredient - ornithine, or diaminovaleric acid. It pertains in itself to detoxicants, antidotes and hepatoprotectors. How does she work? At the very beginning of the rating, it was said that the liver takes part in the final breakdown of unwanted proteins, and this is true. It converts all nitrogen-containing substances to urea, which is highly soluble, and is the final product of nitrogen metabolism. Urea is eliminated from the blood by the kidneys. But in order to produce urea, there is a so-called ornithine cycle in the liver, and ornithine is required for the utilization of unwanted proteins.
In the case when the patient has liver failure, there are signs of liver fibrosis, and there are few healthy cells, and the ornithine cycle is bad, then residual nitrogen accumulates in the blood. Its high concentration is one of the manifestations of liver failure. Therefore, the addition of substrate, or ornithine, allows you to optimize this cycle and increase the production of urea. As a result, the concentration of residual nitrogen and urea in the blood plasma decreases, and the patient's condition improves.
Hepa-merz is shown in liver failure, with a high level of urea, and is available in the form of granules for solution preparation. The drug is used after a meal, one or two bags, dissolved in one glass of water, three times a day. The average daily dose is three sachets. The cost of one package in 30 bags, designed for a 10-day reception is 1700 rubles. This drug is produced by the German company Merz Pharma. Thus, the cost of a monthly course is more than 5,000 rubles.
Advantages and disadvantages
The great advantage of this remedy is a significant continuation of life in patients with liver failure, for example, this remedy helps to normalize the ionic composition of the blood plasma and wait for such an important operation as a liver transplant. But at the same time, improving the quality of life, the drug may be contraindicated, and especially when there is already developed renal failure with high levels of Creatine.
Heptral (admethionine)
Rating: 4.8
The latest drug, presented in the rating, which is actively prescribed by hepatologists and gastroenterologists by patients with severe metabolic disorders and toxic liver damage, is Heptral, or admetionin. This is a derivative of methionine, with regular intake, the agent relieves intoxication, has antioxidant activity, improves the secretion of bile, protects the membranes of hepatocytes and simultaneously has an antidepressant effect.
Admethionine takes an important part in the processes of transamination and transamination, which suffer from progressive liver failure and chronic liver damage. Heptrale is shown in chronic hepatitis, cholestasis, cirrhosis of the liver, in its toxic damage, ranging from professional intoxication with heavy metal salts, to chronic alcoholism. The drug is prescribed at a dosage of 25 mg per kilogram of the patient per day. For example, with intrahepatic cholestasis, its average dose is 1000 mg per day, that is, 1 g. The drug is available in tablets of 500 mg, and one pack of 20 tablets costs about 1,700 rubles. The duration of the course is determined by a doctor - a hepatologist, an infectious diseases specialist or a gastroenterologist.
Advantages and disadvantages
Heptral has been used for about 20 years in the complex therapy of chronic liver disease, and even in the treatment of depressive states, it is well tolerated, improves the quality of life, and its only drawback is the relatively high cost and tonic effect. Therefore, it is not recommended to use Heptral in bed. If this remedy is used against the background of liver failure and against the background of high levels of residual nitrogen, then patients with such a diagnosis should be monitored - the determination of residual nitrogen in blood plasma, as well as urea.
Ideal hepatoprotector
In conclusion, I would like to say about the ideal hepatoprotector. As you know, in medicine, to improve the condition of the patient, it is not always necessary to give something, but sometimes it takes something to take away. The latter type of treatment is only in the interests of the patient, because at the same time neither the pharmacy nor the drug manufacturer will receive anything. The liver is so loaded with work that short periods of fasting, no longer than three days in the absence of contraindications and after a medical examination, lead to a significant improvement in many patients with chronic liver disease. Pain and heaviness in the right hypochondrium decrease, sleep and appetite normalize.
The liver, left to itself, can finally find time and devote much more energy to self-purification than under normal conditions, when more than half of its workload is involved in digestion. Therefore, in the event that you find the strength to give up alcohol, eat right, give up the uncontrolled use of various drugs in the form of self-medication, and at the same time gave the liver two or three days of unloading in the form of a short fasting course, then it is only will do you good.
Attention! This rating is subjective, is not advertising and does not serve as a guide to the purchase. Before buying, you should consult with a specialist.
